Excellent oligodendrocyte marker for IHC!
- 100 µl
- Protein A Purified
- Human, Mouse, Rat
- WB 1:3,000IHC 1:100IP 1:50ICC 1:100
- Rabbit polyclonal
- Gene Name:
- Molecular Reference:
- ~27 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1537-Olig1, RRID:AB_2492192
The antigen is a recombinant mouse Olig1.
The antibody is Protein A purified rabbit serum.
Biological Significance: ExpandCollapse
Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004).