Olig1 Antibody

Catalog #: 1537-Olig1 Categories: , , Datasheet:

$109.00$365.00

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Excellent oligodendrocyte marker for IHC!

Formulation:
Protein A Purified
Species Reactivity:
Human, Mouse, Rat
Applications:
WB 1:3000IHC 1:100IP 1:50ICC 1:100
Species:
Rabbit polyclonal
Gene Name:
OLIG1
Molecular Reference:
~27 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1537-Olig1, RRID:AB_2492192
Antigen/Purification: ExpandCollapse

The antigen is a recombinant mouse Olig1.

The antibody is Protein A purified rabbit serum.

Biological Significance: ExpandCollapse

Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004).

Synonyms: ExpandCollapse

• Basic domain helix loop helix protein class B 6 antibody
• Basic domain helix loop helix protein class B6 antibody
• BHLH B6 antibody
• BHLHB 6 antibody
• bHLHb6 antibody
• bHLHe21 antibody
• Class B basic helix-loop-helix protein 6 antibody
• Class E basic helix-loop-helix protein 21 antibody
• Olig 1 antibody
• Olig1 antibody
• OLIG1_HUMAN antibody
• Oligo 1 antibody
• Oligo1 antibody
• Oligodendrocyte lineage transcription factor 1 antibody
• Oligodendrocyte specific bHLH transcription factor 1 antibody
• Oligodendrocyte transcription factor 1 antibody

Storage

100 µl liquid in 100 mM Glycine, 200 mM Tris, pH 8.0. Contains no preservative. Adequate amount of material to conduct 10-mini Western Blots.

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

General References

Zhou Q, Wang S, Anderson DJ (2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25(2):331-43.

Arnett, H.A., et al. (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306(5704):2111-5.

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Olig1 Antibody
Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 27 kDa Olig1 protein.
Olig1 Antibody
Immunostaining of primary rat oligodendrocytes using anti-Olig1.

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