Olig1 Antibody

Catalog #: 1537-Olig1 Categories: , , Datasheet:

$365.00

Excellent oligodendrocyte marker for IHC!

Size:
100 µl
Formulation:
Protein A Purified
Specificity:
Human, Mouse, Rat
Applications:
WB 1:3,000IHC 1:100IP 1:50ICC 1:100
Species:
Rabbit polyclonal
Gene Name:
OLIG1
Molecular Reference:
~27 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1537-Olig1, RRID:AB_2492192
Antigen/Purification: ExpandCollapse

The antigen is a recombinant mouse Olig1.

The antibody is Protein A purified rabbit serum.

Biological Significance: ExpandCollapse

Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004).

Storage

Liquid in 100 mM Glycine, 200 mM Tris, pH 8.0. Contains no preservative.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least one year after date of receipt. Avoid freeze/thaw cycles.

General References

Zhou Q, Wang S, Anderson DJ (2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25(2):331-43.

Arnett, H.A., et al. (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306(5704):2111-5.

Olig1 Antibody
Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 27 kDa Olig1 protein.
Olig1 Antibody
Immunostaining of primary rat oligodendrocytes using anti-Olig1.

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