Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Bovine, Non-human primate, Sheep, Canine
- WB 1:1,000
- Molecular Reference:
- ~65 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1305-241, RRID:AB_2492155
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser241 of mouse Munc18-1.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho- peptide affinity columns.
Biological Significance: ExpandCollapse
Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.