Rabbit polyclonal antibody
- Affinity purified
- Species Reactivity:
- Rat, Mouse, Human
- WB 1:1000IHC 1:500
- Gene Name:
- Molecular Weight:
- ~125 kDa and ~250 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 2032-mGluR5/1, RRID:AB_2492152
The antigen is a peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.
The antibody is prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Biological Significance: ExpandCollapse
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
• glutamate receptor, metabotropic 5
• GPRC1EMGLUR5metabotropic glutamate receptor 5