Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Sheep, Guinea Pig
- WB 1:1000
- Gene Name:
- Molecular Reference:
- ~55 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1180-394, RRID:AB_2492136
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser394 of human HDAC2.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Histone Deacetylase 2 (HDAC2) is part of a family of histone deacetylases that are responsible for deacetylation of lysine residues in the histone core. HDAC2 is classified as a class I histone deacetylase and is ubiquitously expressed throughout the body (Kee et al, 2008). It has been shown that HDAC2 plays an important role in cardiac hypertrophy (Eom et al, 2011). Phosphorylation of ser394 is responsible for the hypertrophy-associated activation of HDAC2, whereas intrinsic basal activity is maintained by phosphorylation of Ser422 and Ser424 (EOM et al, 2011).