Affinity purified from pooled serum. Learn more.

GRIP1 Associated Protein 1 (GRASP1) Antibody

Catalog #: 642-GRASP Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Bovine, Canine
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
GRIPAP1
Molecular Reference:
~95 kDa
Cite This Antibody:
PhosphoSolutions Cat# 642-GRASP, RRID:AB_2492135
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat GRASP1, conjugated to keyhole limpet hemocyanin (KLH).

The antibody is prepared from rabbit serum by affinity purification via chromatography on an affinity column prepared with the C-terminal peptide used as antigen.

Biological Significance: ExpandCollapse

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).

Synonyms: ExpandCollapse

• DKFZp434P0630 antibody
• DXImx47e antibody
• GRAP1_HUMAN antibody
• GRASP 1 antibody
• GRASP-1 antibody
• GRASP1 antibody
• GRIP 1 associated protein 1 antibody
• GRIP associated protein 1 antibody
• GRIP1 associated protein 1 antibody
• GRIP1-associated protein 1 antibody
• GRIPAP 1 antibody
• GRIPAP1 antibody
• KIAA1167 antibody
• MGC126593 antibody
• MGC126595 antibody
• MPMGp800B12492Q3 antibody
• Sfc10 antibody
• TAMALIN antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

General References

Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141. Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.

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GRIP1 Associated Protein 1 (GRASP1) Antibody
Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95 kDa GRASP protein.

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