Rabbit polyclonal antibodyPooled Serum
- 200 µg
- Affinity Purified from Pooled Serum
- Species Tested:
- Rat, Mouse, Human
- WB 1:1000IHC 1:1000 Don't see your application?
- Molecular Weight:
- ~48 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 700-GLY, RRID:AB_2492133
The antigen is a peptide from the N-terminus region of the α1-subunit of rat glycine receptor.
The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Biological Significance: ExpandCollapse
Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001; Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002).
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