Affinity purified from pooled serum. Learn more.

GluR2/3 Antibody

Catalog #: 905-GluR2/3 Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Chicken, Zebra fish
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
GRIA2/3
Molecular Reference:
~100 kDa
Cite This Antibody:
PhosphoSolutions Cat# 905-GluR2/3, RRID:AB_2492130
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3.

The antibody is prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.

Biological Significance: ExpandCollapse

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002).

Synonyms: ExpandCollapse

• AMPA selective glutamate receptor 2 antibody
• AMPA selective glutamate receptor 3 antibody
• GluR K2 antibody
• GluR K3 antibody
• GLURB antibody
• GLURC antibody
• GLUTAMATE RECEPTOR 2 antibody
• GLUTAMATE RECEPTOR 3 antibody
• Glutamate receptor ionotropic AMPA 2 antibody
• Glutamate receptor ionotropic AMPA 3 antibody
• GRIA2 antibody
• GRIA3 antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

General References

Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.

Duprat F, Daw M, Lim W, Collingridge G, Isaac J (2003) GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity. Philos Trans R Soc Lond B Biol Sci 358:715-720.

Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.

Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.

Seidenman KJ, Steinberg JP, Huganir R, Malinow R (2003) Glutamate receptor subunit 2 serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells. J Neurosci 23:9220-9228.

Yan J, Zhang YF, Jia ZP, Taverna FA, McDonald RJ, Muller RU, Roder JC (2002) Place-cell impairment in glutamate receptor 2 mutant mice. J Neurosci 22:NIL7-NIL11.

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GluR2/3 Antibody
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100 kDa GluR2/3 protein.

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