Rabbit polyclonal antibody
- Affinity purified
- Rat, Mouse, Human, Chicken, Non-human primate, Zebra fish
- WB 1:1000
- Rabbit Polyclonal
- Gene Name:
- Molecular Reference:
- ~100 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1170-880, RRID:AB_2492131
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho Ser880 of rat GluR2.
The antibody is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The number of GluR2 subunits in the AMPA receptor complex affects the Ca2+ permeability, rectification and single-channel conductance of AMPA receptors. Ser880 has been identified as the PKC phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1 (Matsuda et al., 1999)