Affinity purified from pooled serum. Learn more.

GluR2 Antibody

Catalog #: 900-GluR2 Category: Datasheet:

$365.00

Rabbit polyclonal antibody

Pooled Serum
Size:
100 µl
Formulation:
Affinity Purified from Pooled Serum
Specificity:
Rat, Mouse, Human, Chicken, Non-human primate, Zebra fish
Applications:
WB 1:1,000
Species:
Rabbit
Gene Name:
GRIA2
Molecular Reference:
~100 kDa
Cite This Antibody:
PhosphoSolutions Cat# 900-GluR2, RRID:AB_2492129
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH).

The antibody is prepared from pooled rabbit serum by affinity purification on a column made with the peptide antigen.

Biological Significance: ExpandCollapse

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003).

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

Product Specific References

Mao, L.M., He, N., Jin, D.Z. and Wang, J.Q., 2018. Regulation of Phosphorylation of AMPA Glutamate Receptors by Muscarinic M4 Receptors in the Striatum In vivo. Neuroscience, 375, pp.84-93. PMID: 29432883

Lameth, J., Gervais, A., Colin, C., Lévêque, P., Jay, T.M., Edeline, J.M. and Mallat, M., 2017. Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the Rat Cerebral Cortex. Neurotoxicity Research, pp.1-16. PMID: 28578480

 

GluR2 Antibody
Western blot of a rat hippocampal lysate showing the specific immunolabeling of the ~100 kDa GluR2 protein.

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