Rabbit polyclonal antibodyPooled Serum
- 100 µl
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Chicken, Non-human primate, Zebra fish
- WB 1:1,000
- Gene Name:
- Molecular Reference:
- ~100 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 900-GluR2, RRID:AB_2492129
The antigen is a peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH).
The antibody is prepared from pooled rabbit serum by affinity purification on a column made with the peptide antigen.
Biological Significance: ExpandCollapse
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003).