Affinity purified from pooled serum. Learn more.

GluR1 (Ser831) Antibody

Catalog #: p1160-831 Category: Datasheet:


  • SizePrice

Rabbit polyclonal antibody

Pooled Serum
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Chicken, Canine
WB 1:1000
Gene Name:
Molecular Reference:
~100 kDa
Cite This Antibody:
PhosphoSolutions Cat# p1160-831, RRID:AB_2492127
Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

Biological Significance: ExpandCollapse

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by ?-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II (McGlade-McCulloh et al., 1993; Mammen et al., 1999; Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory (Soderling and Derkach, 2000).

Synonyms: ExpandCollapse

• GLUR 1 antibody
• GLUR A antibody
• AMPA 1 antibody
• AMPA selective glutamate receptor 1 antibody
• AMPA-selective glutamate receptor 1 antibody
• GluA1 antibody
• GLUH1 antibody
• GluR K1 antibody
• GluR-1 antibody
• GluR-A antibody
• GluR-K1 antibody
• GLUR1 antibody
• GLURA antibody
• GluRK1 antibody
• Glutamate receptor 1 antibody
• Glutamate receptor ionotropic AMPA 1 antibody
• Glutamate receptor ionotropic antibody
• Glutamate receptor, ionotropic, AMPA 1 antibody
• Gria1 antibody
• GRIA1_HUMAN antibody
• HBGR1 antibody
• MGC133252 antibody
• OTTHUMP00000160643 antibody
• OTTHUMP00000165781 antibody
• OTTHUMP00000224241 antibody
• OTTHUMP00000224242 antibody
• OTTHUMP00000224243 antibody


100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Mao, L.M., He, N., Jin, D.Z. and Wang, J.Q., 2018. Regulation of Phosphorylation of AMPA Glutamate Receptors by Muscarinic M4 Receptors in the Striatum In vivo. Neuroscience, 375, pp.84-93. PMID: 29432883

Xue, B., Mao, L.M., Jin, D.Z. and Wang, J.Q., 2017. Pharmacological modulation of AMPA receptor phosphorylation by dopamine and muscarinic receptor agents in the rat medial prefrontal cortex. European journal of pharmacology. 2017 Dec 11;820:45-52. PMID: 29242119

Lameth, J., Gervais, A., Colin, C., Lévêque, P., Jay, T.M., Edeline, J.M. and Mallat, M., 2017. Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the Rat Cerebral Cortex. Neurotoxicity Research, pp.1-16. PMID: 28578480

Xue, B., Chen, E. C., He, N., Jin, D. Z., Mao, L. M., & Wang, J. Q. (2016). Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine. Neuropharmacology. PMID: 27060412

O’Leary, H., Bernard, P. B., Castano, A. M., & Benke, T. A. (2016). Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure. Neurobiology of disease, 87, 134-144. PMID: 26706598

Bean, L.A., Kumar, A., Rani, A., Guidi, M., Rosario, A.M., Cruz, P.E., Golde, T.E. and Foster, T.C., 2015. Re-opening the critical window for estrogen therapy. Journal of Neuroscience, 35(49), pp.16077-16093. PMID: 26658861

Pasek, J. G., Wang, X., & Colbran, R. J. (2015). Differential CaMKII regulation by voltage-gated calcium channels in the striatum. Molecular and Cellular Neuroscience, 68, 234-243. PMID: 26255006

Mao, L. M., Xue, B., Jin, D. Z., & Wang, J. Q. (2015). Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine. Journal of neurochemistry. Jun;133(6):795-805. PMID: 25689263

Mao, L. M., Hastings, J. M., Fibuch, E. E., & Wang, J. Q. (2014). Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice. European journal of pharmacology, 738, 237-244.  PMID: 24907515

Xue, B., Edwards, M. C., Mao, L. M., Guo, M. L., Jin, D. Z., Fibuch, E. E., & Wang, J. Q. (2014). Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration. Neurochemistry international, 64, 48-54.  PMID: 24231469

Barcomb, K., Coultrap, S. J., & Bayer, K. U. (2013). Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Molecular pharmacology, 84(6), 834-843. PMID: 24056996

Jalan-Sakrikar, N., Bartlett, R.K., Baucum, A.J. and Colbran, R.J., 2012. Substrate-selective and calcium-independent activation of CaMKII by ?-actinin. Journal of Biological Chemistry, 287(19), pp.15275-15283. PMID: 22427672

Yuxia Jiao, Nidhi Jalan-Sakrikar, A. J. Robison, Anthony J. Baucum, II, Martha A. Bass, and Roger J. Colbran (2011) Characterization of a Central Ca2+/Calmodulin-dependent Protein Kinase II?/? Binding Domain in Densin That Selectively Modulates Glutamate Receptor Subunit Phosphorylation. J. Biol. Chem. 286: 24806 – 24818. PMID: 21610080

Robert M. Sears, Rong-Jian Liu, Nandakumar S. Narayanan, Ruth Sharf, Mark F. Yeckel, Mark Laubach, George K. Aghajanian, and Ralph J. DiLeone (2010) Regulation of Nucleus Accumbens Activity by the Hypothalamic Neuropeptide Melanin-Concentrating Hormone J. Neurosci., 30: 8263 – 8273. PMID: 20554878

Steven J. Coultrap, Isabelle Buard, Jaqueline R. Kulbe, Mark L. Dell’Acqua, and K. Ulrich Bayer (2010) CaMKII Autonomy Is Substrate-dependent and Further Stimulated by Ca2+/Calmodulin. J. Biol. Chem., 285: 17930 – 1793. PMID: 20353941

Kurtis D. Davies, Susan M. Goebel-Goody, Steven J. Coultrap, and Michael D. Browning (2008) Long Term Synaptic Depression That Is Associated with GluR1 Dephosphorylation but Not ?-Amino-3-hydroxy-5-methyl-4- isoxazolepropionic Acid (AMPA) Receptor Internalization J. Biol. Chem., 283: 33138 – 33146. PMID: 18819923

Sergio Leal-Ortiz, Clarissa L. Waites, Ryan Terry-Lorenzo, Pedro Zamorano, Eckart D. Gundelfinger, and Craig C. Garner (2008) Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. J. Cell Biol., 181: 831 – 846. PMID: 18519737

Hu, H., Real, E., Takamiya, K., Kang, M.G., Ledoux, J., Huganir, R.L. and Malinow, R., 2007. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell, 131(1), pp.160-173. PMID: 17923095


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GluR1 ser831 Antibody
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100 kDa GluR1 protein phosphorylated at Ser831 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min).

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