Great for staining the plasma membrane of neurons!
- 100 µl
- Total IgY fraction
- Rat, Mouse, Human
- WB 1:2,000IF 1:500
- Chicken polyclonal
- Gene Name:
- Molecular Reference:
- ~43 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 875-GAP43, RRID:AB_2492122
The antigen is a synthetic peptide corresponding to amino acid residues from the C-terminal region of the rat GAP43 sequence.
The antibody is total IgY fraction.
Biological Significance: ExpandCollapse
GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).