Affinity purified from pooled serum. Learn more.

Gap-43 (Ser41) Antibody

Catalog #: p1150-41 Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Xenopus, Bovine, Chicken, Non-human primate, Zebra fish, Canine
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
GAP43
Molecular Reference:
~50 kDa
Cite This Antibody:
PhosphoSolutions Cat# p1150-41, RRID:AB_2492123
Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser41 of Gap-43.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

Biological Significance: ExpandCollapse

Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser 41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).

Synonyms: ExpandCollapse

• Axonal membrane protein GAP 43 antibody
• Axonal membrane protein GAP-43 antibody
• B 50 antibody
• Calmodulin binding protein P 57 antibody
• F1 antibody
• GAP 43 antibody
• GAP-43 antibody
• GAP43 antibody
• Growth Associated Protein 43 antibody
• Growth-associated protein 43 antibody
• Nerve Growth Related Peptide antibody
• Nerve growth related peptide GAP43 antibody
• NEUM_HUMAN antibody
• Neural phosphoprotein B 50 antibody
• Neural phosphoprotein B-50 antibody
• Neuromodulin antibody
• Neuron growth associated protein 43 antibody
• PP46 antibody
• Protein F1 antibody
• QtrA-11580 antibody
• QtrA-13071 antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Rayudu Gopalakrishna, Usha Gundimeda, Jason Eric Schiffman, and Thomas H. McNeill (2008) A Direct Redox Regulation of Protein Kinase C Isoenzymes Mediates Oxidant-induced Neuritogenesis in PC12 Cells J. Biol. Chem., May 2008; 283: 14430 – 14444. PMID: 18375950

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Gap-43 ser41 Antibody
Western blot of rat cortical lysate showing specific immunolabeling of the ~50 kDa Gap-43 protein phosphorylated at Ser41 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min).

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