Affinity purified from pooled serum. Learn more.

GABAA Receptor, δ-Subunit, N-Terminus Antibody

Catalog #: 868A-GDN* Category: Datasheet:

$109.00$365.00

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Rabbit Polyclonal Antibody

*This antibody is a replacement for our original catalog #868-GDN. It was
produced by the same methods, using the same fusion protein antigen
in new animals.

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Mouse, Rat
Applications:
WB 1:1000
Species:
Rabbit Polyclonal
Gene Name:
GABRD
Molecular Reference:
~50 kDa
Cite This Antibody:
PhosphoSolutions Cat# 868A-GDN, RRID:AB_2631037
Antigen/Purification: ExpandCollapse

The antigen is a fusion protein from the N-terminal region of the δ-subunit of rat GABAA receptor.

The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.

Biological Significance: ExpandCollapse

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl channel associated with the GABAA receptor (GABAA-R) subtype.  GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression and substance abuse.  The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin,1990; Whiting et al., 1999; Ogris et al., 2004).  Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a g-subunit is required for benzodiazepine modulation.  The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).  More recently there have been a number of studies demonstrating that the δ-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).

Synonyms: ExpandCollapse

• GABA(A) receptor subunit delta antibody
• Gabrd antibody
• Gamma aminobutyric acid GABA A receptor delta antibody
• Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody
• Gamma-aminobutyric acid receptor subunit delta antibody
• GBRD_HUMAN antibody
• MGC45284 antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Zhou, L., Tang, X., Li, X., Bai, Y., Buxbaum, J.N. and Chen, G., 2019. Identification of transthyretin as a novel interacting partner for the ? subunit of GABAA receptors. PloS one14(1), p.e0210094. PMID: 30615651

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GABA A delta subunit n terminus
Western blot of mouse whole brain (1) and mouse synaptic plasma membrane (2) lysates showing specific immunolabeling of the ~50 kDa δ-subunit of the GABAA-R.

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