Rabbit polyclonal antibody
- Affinity purified
- 100% Homology:
- Rat, Mouse
- WB 1:100-200IHC 1:100-200
- Gene Name:
- Molecular Reference:
- ~67 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 881-GAT2, RRID:AB_2492120
The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat GAT-2.
The antibody is prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.
Biological Significance: ExpandCollapse
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by highaffinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999)