GABA Transporter (GAT) 2 Antibody

Catalog #: 881-GAT2 Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Formulation:
Affinity purified
100% Homology:
Rat, Mouse
Applications:
WB 1:100-200IHC 1:100-200
Species:
Rabbit
Gene Name:
SLC6A13
Molecular Reference:
~67 kDa
Cite This Antibody:
PhosphoSolutions Cat# 881-GAT2, RRID:AB_2492120
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat GAT-2.

The antibody is prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.

Biological Significance: ExpandCollapse

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by highaffinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999)

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

Product Specific References

Johnson, J., Chen, T. K., Rickman, D. W., Evans, C., & Brecha, N. C. (1996). Multiple γ-aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina. The Journal of comparative neurology, 375(2), 212.  PMID: 8915826

GAT2 Western Blot Image
Western blot of mouse whole brain lysate showing specific immunolabeling of the ~67 kDa GAT-2 protein.

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