Rabbit polyclonal antibody
- Affinity purified
- 100% Homology:
- Rat, Mouse
- WB 1:1,000IHC 1:100-1:200
- Gene Name:
- Molecular Reference:
- ~67 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 880-GAT1, RRID:AB_2492119
The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
The antibody is prepared from rabbit serum by affinity purification via chromatography with a column made with the peptide used as antigen.
Biological Significance: ExpandCollapse
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by highaffinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).