GABAA Receptor α1 Antibody

Catalog #: 811-GA1C Category: Datasheet:

$109.00 – $365.00

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Rabbit polyclonal antibody

Formulation:
Affinity purified
Species Reactivity:
Rat, Mouse, Human, Bovine, Non-human primate, Canine
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
GABRA1
Molecular Reference:
~51 kDa
Cite This Antibody:
PhosphoSolutions Cat# 811-GA1C, RRID:AB_2492099
Antigen/Purification: ExpandCollapse

The antigen is a fusion protein from the cytoplasmic loop of the ?1-subunit of rat GABAA receptor.

The antibody is prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.

Biological Significance: ExpandCollapse

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six ?s, four ?s and four ?s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for ?- and ?-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a ?-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different ?- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

Synonyms: ExpandCollapse

• ECA4 antibody
• EIEE19 antibody
• EJM antibody
• EJM5 antibody
• Gaba receptor alpha 1 polypeptide antibody
• GABA(A) receptor antibody
• GABA(A) receptor subunit alpha 1 antibody
• GABA(A) receptor subunit alpha-1 antibody
• GABA(A) receptor, alpha 1 antibody
• GABRA 1 antibody
• GABRA1 antibody
• Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody
• Gamma aminobutyric acid A receptor alpha 1 antibody
• Gamma aminobutyric acid receptor subunit alpha 1 antibody
• Gamma aminobutyric acid type A receptor alpha1 subunit antibody
• Gamma-aminobutyric acid receptor subunit alpha-1 antibody
• GBRA1_HUMAN antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Wang, P., Eshaq, R. S., Meshul, C. K., Moore, C., Hood, R. L., & Leidenheimer, N. J. (2015). Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Frontiers in Cellular Neuroscience, 9, 188. PMID: 26041994

Herman, M. A., & Roberto, M. (2014). Cell?type?specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol. Addiction biology. Aug. 29. PMID: 25170988

Mridula Rewal, Rachel Jurd, T. Michael Gill, Dao-Yao He, Dorit Ron, and Patricia H. Janak (2009) alpha-4-Containing GABAA Receptors in the Nucleus Accumbens Mediate Moderate Intake of Alcohol J. Neurosci., 29: 543-549. PMID: 19144854

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GABA A Receptor alpha 1 Antibody
Western blot of mouse forebrain lysates from wild type (WT) and ?1-knockout (K/O) animals showing specific immunolabeling of the ~51 kDa ?1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from ?1-knockout animals.

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