Mouse monoclonal antibody
- Protein G Purified
- WB 1:1000IHC 1:500
- Mouse Monoclonal
- Molecular Reference:
- ~85 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 540-EWS, RRID:AB_2650521
The antigen is recombinant full length human EWS expressed in and purified from E. Coli.
The antibody is Protein G purified from culture supernatant.
Biological Significance: ExpandCollapse
The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins. EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008). Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016). Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016).