Rabbit Polyclonal AntibodyPooled Serum
- Affinity Purified from Pooled Serum
- Bovine, Human, Mouse, Non-human primate, Rat
- WB 1:1000
- Rabbit Polyclonal
- Molecular Reference:
- ~ 46 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 495-eIF4A2, RRID:AB_2630324
The antigen is a peptide from the N-terminal region of the human eIF4A2 protein.
The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Biological Significance: ExpandCollapse
The eIF4A, eukaryotic initiation factor 4A, are a set of proteins, eIF4A1, eIF4A2, and eIF4A3, that belong to the extensive DEAD-box RNA helicase family (Weinstein et al., 1997). They are involved in many aspects of RNA metabolism by virtue of their RNA-binding capacity and ATPase activity (Lu et al., 2014). eIF4A2 is a highly conserved gene for one of the protein-synthesis initiation factors involved in the binding of mRNA to the ribosome (Gingras et al., 1999). In humans eIF4A2 is expressed in all normal tissues, though highly expressed in skeletal muscle (Sudo et al., 1995). Studies suggest eIF4A2 may play a role in some cancers, specifically breast and lung cancer, along with melanoma (Shaoyan et al., 2013).