Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- 100% Homology:
- Rat, Mouse, Human, Non-human primate, Zebra fish, Canine
- WB 1:1,000
- Gene Name:
- Molecular Reference:
- ~46 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p155-383, RRID:AB_2492085
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser383 of human Elk-1.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Elk-1 is a transcription factor involved in mediating gene transcription in response to growth factors (Hill and Treisman, 1995). Elk-1 is thought to be phosphorylated by MAP kinase at Ser383 and phosphorylation at this site is essential for the transcriptional activity of Elk-1 (Li et al., 2003). Phosphorylation of Elk-1 has also been implicated in synaptic plasticity in the adult hippocampus (Thiels et al., 2002).