Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Bovine, Chicken, Non-human primate
- WB 1:1,000
- Gene Name:
- Molecular Reference:
- ~95 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 480-DYN, RRID:AB_2492081
The antigen is a peptide corresponding to amino acid residues from the N-terminal region of human Dynamin, conjugated to keyhole limpet hemocyanin (KLH).
The antibody is prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column made with the N-terminal peptide used as antigen.
Biological Significance: ExpandCollapse
Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis (Cousin et al., 2001; Graham et al., 2002; Tsuboi et al., 2002). There are 3 known isoforms of Dynamin, each having several splice variants as well. Dynamin I is expressed only in neurons whereas Dynamin II is ubiquitously expressed and Dynamin III is found primarily in the testes. Dynamin 1 is phosphorylated by PKC and dephosphorylated by calcineurin.