Excellent marker for IHC!
- Affinity Purified from Pooled Serum
- Mouse, Human, Non-human primate
- WB 1:1,000IHC 1:1,000
- Rabbit polyclonal
- Gene Name:
- Molecular Reference:
- ~88 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 431-DATC, RRID:AB_2492076
The antigen is a peptide from the intracellular C-terminus region of human dopamine transporter (DAT), conjugated to keyhole limpet hemocyanin (KLH).
The antibody is prepared from pooled rabbit serum by affinity purification using a SulfoLink® column matrix to which the peptide immunogen was coupled.
Biological Significance: ExpandCollapse
The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996).