Affinity purified from pooled serum. Learn more.

Dopamine β-Hydroxylase Antibody, N-Terminus

Catalog #: 423-DBHN Categories: , , , Datasheet:

$109.00$365.00

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Sheep polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Human, Non-human primate
Applications:
WB 1:1000
Species:
Sheep
Gene Name:
DBH
Molecular Reference:
~75 kDa
Cite This Antibody:
PhosphoSolutions Cat# 423-DBHN, RRID:AB_2492075
Antigen/Purification: ExpandCollapse

The antigen is a peptide from the N-terminal region of human dopamine ?-hydroxylase (DBH), conjugated to keyhole limpet hemocyanin (KLH).

The antibody is prepared from sheep serum by affinity purification using a Sulfo-Link® column matrix to which the peptide immunogen was coupled.

Biological Significance: ExpandCollapse

DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001).

Synonyms: ExpandCollapse
  • dbh antibody
  • DBM antibody
  • Dopamine beta hydroxylase antibody
  • Dopamine beta monooxygenase antibody
  • Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody
  • Dopamine beta-monooxygenase antibody
  • DOPO_HUMAN antibody
  • OTTHUMP00000022501 antibody
  • Soluble dopamine beta-hydroxylase antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286. PMID: 10560033

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Dopamine β-Hydroxylase Antibody, N-Terminus
Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75 kDa DBH protein.

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