Affinity purified from pooled serum. Learn more.

DOPA Decarboxylase Antibody, Human

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Specificity:
Rat, Human, Bovine, Sheep, Canine, Rabbit, Guinea Pig
Applications:
WB 1:1,000
Species:
Rabbit
Gene Name:
DDC
Molecular Reference:
~55 kDa
Cite This Antibody:
PhosphoSolutions Cat# 418-DDCH, RRID:AB_2492073
Antigen/Purification: ExpandCollapse

The antigen is a peptide from N-terminus region of human DOPA decarboxylase (DDC), conjugated to keyhole limpet hemocyanin (KLH).

The antibody is prepared from pooled rabbit serum by affinity purification using an AminoLink® Plus column matrix to which purified, recombinant bovine DDC was coupled.

 

Biological Significance: ExpandCollapse

DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

Product Specific References

Waymire JC, Haycock JW (2002) Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells. J Neurochem 81:589-593. PMID: 12065667

DOPA Decarboxylase Antibody, Human
Western blot of 5 µg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55 kDa DOPA decarboxylase protein.

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