- Affinity Purified from Pooled Serum
- Species Tested:
- Human, Mouse
- WB 1:1000 Don't see your application?
- Host Species:
- Rabbit Polyclonal
- Gene Name:
- Molecular Weight:
- ~120 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1035-377, RRID:AB_2492071
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser377 of human DGCR8.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
The Drosha-DGCR8 microprocessor complex is required for microRNA (miRNA) biogenesis. DGCR8 (DiGeorge Syndrome Critical Region 8) recognizes the RNA substrate, whereas Drosha functions as the endonuclease. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, interacts with the pri-miRNA and functions as the molecular anchor that measures the distance from the ds-RNA-ssRNA junction and directs Drosha cleavage 11bp away (Han, J., et al, 2006). The efficiency of Drosha cleavage increases in the presence of heme and promotes the formation of highly ordered DGCR8 structures upon binding to RNA (Faller, M., et al, 2010).
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