Cyclin-dependent kinase 5 (Cdk5) Antibody

Catalog #: 308-CDK5 Category: Datasheet:

$109.00$365.00

  • SizePrice
Clear

Mouse monoclonal antibody

Formulation:
Protein G Purified
Species Reactivity:
Rat, Mouse, Human
Applications:
WB 1:1000IHC 1:500
Species:
Mouse
Gene Name:
CDK5
Molecular Weight:
~ 28 kDa
Cite This Antibody:
PhosphoSolutions Cat# 308-CDK5, RRID:AB_2492053
Antigen/Purification: ExpandCollapse

The antigen is a purified rat Cdk5.

The antibody is protein G purified culture supernatant.

Biological Significance: ExpandCollapse

The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer’s, Parkinson’s, Huntington’s, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.

Synonyms: ExpandCollapse
  • Cdk 5 antibody
  • Cdk5 antibody
  • CDK5_HUMAN antibody
  • Cell division protein kinase 5 antibody
  • Crk6 antibody
  • Cyclin dependent kinase 5 antibody
  • Cyclin-dependent kinase 5 antibody
  • Protein kinase CDK5 splicing antibody
  • PSSALRE antibody
  • Serine threonine protein kinase PSSALRE antibody
  • Serine/threonine-protein kinase PSSALRE antibody
  • Tau protein kinase II catalytic subunit antibody
  • TPKII catalytic subunit antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Hall, B.E., Prochazkova, M., Sapio, M.R., Minetos, P., Kurochkina, N., Binukumar, B.K., Amin, N.D., Terse, A., Joseph, J., Raithel, S.J. and Mannes, A.J., 2018. Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception. Scientific Reports8(1), p.1177. PMID: 29352128

Hernandez, A., Tan, C., Mettlach, G., Pozo, K., Plattner, F., & Bibb, J. A. (2016). Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum. Scientific Reports, 6. PMID: 27443506

Lagace, D. C. et al. Cdk5 is essential for adult hippocampal neurogenesis. Proc Natl Acad Sci USA 105, 18567–18571 (2008).  PMID: 19017796

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Cyclin-dependent kinase 5 (Cdk5) Antibody
Western blot of rat striatal lysate showing specific immunolabeling of the ~28 kDa Cdk5 protein.

You may also like…