Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Bovine, Chicken, Zebra fish, Canine, Guinea Pig
- WB 1:1,000
- Gene Name:
- Molecular Reference:
- ~43 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1007-368, RRID:AB_2492064
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin43.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).