Rabbit polyclonal antibody
Pooled Serum- Formulation:
- Affinity Purified from Pooled Serum
- Specificity:
- Rat, Mouse, Human, Xenopus, Chicken, Non-human primate, Zebra fish, Sheep, Canine
- Applications:
- WB 1:1,000
- Species:
- Rabbit
- Gene Name:
- GJA1
- Molecular Reference:
- ~43 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 327-CON, RRID:AB_2492063
Antigen/Purification: Collapse
The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
The antibody is prepared from pooled rabbit serum by affinity purification on a column made with the C-terminal peptide used as antigen.
Biological Significance: Collapse
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
