Collagen I, alpha 1, telopeptide Antibody

Our rabbit polyclonal Collagen I, alpha 1, telopeptide antibody is affinity purified. It is excellent for use in WB and IHC.

Catalog #: 322-COLT Categories: , Datasheet:

$119.00$380.00

  • SizePrice
Clear
Formulation:
Affinity purified
Species Tested:
Human, Mouse, Rat, Sheep
Expected Reactivity:
Rat, Amphibians, Avian, Most Mammals
Applications:
WB 1:1000IHC 1:100-1:200 Don't see your application?
Host Species:
Rabbit Polyclonal
Gene Name:
COL1A1
Molecular Weight:
~140 kDa
Cite This Antibody:
PhosphoSolutions Cat# 322-COLT, RRID:AB_2492061
Antigen/Purification: ExpandCollapse

The antigen is a synthetic peptide from the C-terminal region of human collagen I α1 telopeptide sequence.

The antibody is affinity purified.

Biological Significance: ExpandCollapse

Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).

Synonyms: ExpandCollapse
  • Alpha 1 type I collagen antibody
  • Alpha 2 type I collagen antibody
  • alpha 2 type I procollagen antibody
  • alpha 2(I) procollagen antibody
  • alpha 2(I)-collagen antibody
  • Alpha-1 type I collagen antibody
  • alpha1(I) procollagen antibody
  • CO1A1_HUMAN antibody
  • COL1A1 antibody
  • COL1A2 antibody
  • collagen alpha 1 chain type I antibody
  • Collagen alpha-1(I) chain antibody
  • collagen alpha-1(I) chain preproprotein antibody
  • Collagen I alpha 1 polypeptide antibody
  • Collagen I alpha 2 polypeptide antibody
  • collagen of skin, tendon and bone, alpha-1 chain antibody
  • collagen of skin, tendon and bone, alpha-2 chain antibody
  • Collagen type I alpha 1 antibody
  • Collagen type I alpha 2 antibody
  • EDSC antibody
  • OI1 antibody
  • OI2 antibody
  • OI3 antibody
  • OI4 antibody
  • pro-alpha-1 collagen type 1 antibody
  • type I proalpha 1 antibody
  • type I procollagen alpha 1 chain antibody
  • Type I procollagen antibody

Storage

Liquid in PBS. Contains no preservative.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C up to six months after date of receipt. Avoid freeze/thaw cycles.

Product Specific Protocols

Immunohistochemistry

Mouse Spinal Cord

Western Blotting

Click here to view our protocols page for Western blotting and lysate preparation.

Product Specific References for Applications and Species

Immunohistochemistry: Human | Mouse


Immunohistochemistry: Human
PMID Dilution Publication
23004679 not listed Bains, S.N., et al. 2012 Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma. Allergy. 2012 Dec;67(12): 1601-4.


Immunohistochemistry: Mouse
PMID Dilution Publication
30117615 1:500 Gatto, R.G., et al. 2018 In vivo diffusion MRI detects early spinal cord axonal pathology in a mouse model of amyotrophic lateral sclerosis. NMR in Biomedicine, Aug;31(8):e3954.
22546693 not listed Wessels, A., et al. 2012 Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012 Jun 15;366(2): 111-24.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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