Collagen I, alpha 1, propeptide Antibody

Our rabbit polyclonal Collagen I, alpha 1, propeptide antibody is affinity purified. It is excellent for use in WB and IHC.

Catalog #: 321-COLP Categories: , Datasheet:

$119.00$380.00

  • SizePrice
Clear
Formulation:
Affinity purified
Species Tested:
Rat, Mouse, Human
Expected Reactivity:
Avian, Amphibians, Most Mammals
Applications:
WB 1:1000IHC 1:100 Don't see your application?
Host Species:
Rabbit Polyclonal
Gene Name:
COL1A1
Molecular Weight:
~180 kDa
Cite This Antibody:
PhosphoSolutions Cat# 321-COLP, RRID:AB_2492060
Antigen/Purification: ExpandCollapse

The antigen is a peptide from the human collagen I α1 propeptide sequence.

The antibody is affinity purified.

Biological Significance: ExpandCollapse

Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)

Synonyms: ExpandCollapse
  • Alpha 1 type I collagen antibody
  • Alpha 2 type I collagen antibody
  • alpha 2 type I procollagen antibody
  • alpha 2(I) procollagen antibody
  • alpha 2(I)-collagen antibody
  • Alpha-1 type I collagen antibody
  • alpha1(I) procollagen antibody
  • CO1A1_HUMAN antibody
  • COL1A1 antibody
  • COL1A2 antibody
  • collagen alpha 1 chain type I antibody
  • Collagen alpha-1(I) chain antibody
  • collagen alpha-1(I) chain preproprotein antibody
  • Collagen I alpha 1 polypeptide antibody
  • Collagen I alpha 2 polypeptide antibody
  • collagen of skin, tendon and bone, alpha-1 chain antibody
  • collagen of skin, tendon and bone, alpha-2 chain antibody
  • Collagen type I alpha 1 antibody
  • Collagen type I alpha 2 antibody
  • EDSC antibody
  • OI1 antibody
  • OI2 antibody
  • OI3 antibody
  • OI4 antibody
  • pro-alpha-1 collagen type 1 antibody
  • type I proalpha 1 antibody
  • type I procollagen alpha 1 chain antibody
  • Type I procollagen antibody

Storage

100 µl in PBS. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific Protocols

Western Blotting

Click here to view our protocols page for Western blotting and lysate preparation.

Product Specific References for Applications and Species

Western Blot: Mouse
Flow Cytometry: Mouse


Flow Cytometry: Mouse
PMID Dilution Publication
24999331 1.67ug/ml Reese, C., et al. 2014 Fibrocytes in the fibrotic lung: altered phenotype detected by flow cytometry. Front Pharmacol. 2014 Jun 16;5:141.


Western blot: Mouse
PMID Dilution Publication
24999331 0.2ug/ml Reese, C., et al. 2014 Fibrocytes in the fibrotic lung: altered phenotype detected by flow cytometry. Front Pharmacol. 2014 Jun 16;5:141.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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