Rabbit polyclonal antibody
- Formulation:
- Affinity purified
- 100% Homology:
- Rat, Mouse, Human
- Applications:
- WB 1:1,000IHC 1:100
- Species:
- Rabbit
- Gene Name:
- COL1A1
- Molecular Reference:
- ~180 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 321-COLP, RRID:AB_2492060
Antigen/Purification: Collapse
The antigen is a peptide from the human collagen I α1 propeptide sequence.
The antibody is affinity purified.
Biological Significance: Collapse
Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)
