Collagen I, alpha 1, propeptide Antibody

Catalog #: 321-COLP Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Formulation:
Affinity purified
100% Homology:
Rat, Mouse, Human
Applications:
WB 1:1,000IHC 1:100
Species:
Rabbit
Gene Name:
COL1A1
Molecular Reference:
~180 kDa
Cite This Antibody:
PhosphoSolutions Cat# 321-COLP, RRID:AB_2492060
Antigen/Purification: ExpandCollapse

The antigen is a peptide from the human collagen I α1 propeptide sequence.

The antibody is affinity purified.

Biological Significance: ExpandCollapse

Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)

Storage

100 µl in PBS. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

Product Specific References

Reese C, Lee R, Bonner M, Perry B, Heywood J, Silver RM, Tourkina E, Visconti RP, Hoffman S. (2014) Fibrocytes in the fibrotic lung: altered phenotype detected by flow cytometry. Front Pharmacol. 2014 Jun 16;5:141. PMID: 24999331

Collagen I, alpha 1, propeptide Antibody
Western blot of rat lung lysate showing specific immunolabeling of the ~180 kDa collagen 1.
Collagen I, alpha 1, propeptide Antibody
Immunostaining of fibrotic mouse lung tissue showing specific staining of collagen I molecules (red) that are still associated with the cells in which they were synthesized.

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