Rabbit polyclonal antibody
- Formulation:
- Affinity purified
- Species Tested:
- Rat, Mouse, Human
- Species Reactivity:
- Avian, Amphibians, Most Mammals
- Applications:
- WB 1:1000IHC 1:100 Don't see your application?
- Species:
- Rabbit
- Gene Name:
- COL1A1
- Molecular Weight:
- ~180 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 321-COLP, RRID:AB_2492060
Antigen/Purification: Collapse
The antigen is a peptide from the human collagen I α1 propeptide sequence.
The antibody is affinity purified.
Biological Significance: Collapse
Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)
Synonyms: Collapse
- Alpha 1 type I collagen antibody
- Alpha 2 type I collagen antibody
- alpha 2 type I procollagen antibody
- alpha 2(I) procollagen antibody
- alpha 2(I)-collagen antibody
- Alpha-1 type I collagen antibody
- alpha1(I) procollagen antibody
- CO1A1_HUMAN antibody
- COL1A1 antibody
- COL1A2 antibody
- collagen alpha 1 chain type I antibody
- Collagen alpha-1(I) chain antibody
- collagen alpha-1(I) chain preproprotein antibody
- Collagen I alpha 1 polypeptide antibody
- Collagen I alpha 2 polypeptide antibody
- collagen of skin, tendon and bone, alpha-1 chain antibody
- collagen of skin, tendon and bone, alpha-2 chain antibody
- Collagen type I alpha 1 antibody
- Collagen type I alpha 2 antibody
- EDSC antibody
- OI1 antibody
- OI2 antibody
- OI3 antibody
- OI4 antibody
- pro-alpha-1 collagen type 1 antibody
- type I proalpha 1 antibody
- type I procollagen alpha 1 chain antibody
- Type I procollagen antibody
