CNP (CNPase) Antibody

Catalog #: 325-CNP Categories: , , Datasheet:

$310.00

Great marker for oligodendrocytes and Schwann cells!

Size:
50 µl
Formulation:
Neat serum
Species Reactivity:
Rat, Mouse, Human, Sheep, Rabbit
Applications:
WB 1:1000IHC 1:10
Species:
Rabbit polyclonal
Gene Name:
CNP
Molecular Reference:
~46 kDa
Cite This Antibody:
PhosphoSolutions Cat# 327-CON, RRID:AB_2492063
Antigen/Purification: ExpandCollapse

The antigen is an endogenous rabbit 2,3-cyclic nucleotide-3-phospho-diesterase.

The antibody is neat serum.

Biological Significance: ExpandCollapse

2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).

Synonyms: ExpandCollapse
  • 2” antibody
  • 2’3′ cyclic nucleotide 3′ phosphodiesterase antibody
  • 3”-cyclic-nucleotide 3”-phosphodiesterase antibody
  • CN37_HUMAN antibody
  • CNP 1 antibody
  • CNP antibody
  • CNP1 antibody
  • CNPase antibody

Storage

50 ul neat serum.

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Product Specific References

González-Fernández, E., Jeong, H.K., Fukaya, M., Kim, H., Khawaja, R.R., Srivastava, I.N., Waisman, A., Son, Y.J. and Kang, S.H., 2018. PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling. eLife, 7, p.e32021. PMID: 29461205

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CNP (CNPase) Antibody
Western blot of rat brain lysate showing the specific immunolabeling of the ~46 kDa CNP protein.
CNP (CNPase) Antibody
Immunochemical staining of saline treated mouse cortex cryosections showing specific labeling of CNP in green and DNA in blue. Photo courtesy of Robert Wine.

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