Clavesin 1/2 Antibody

Catalog #: 317-CLAV Categories: , , Datasheet:

$109.00$365.00

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Neuronal marker for ICC and Western blot

Formulation:
Affinity purified
Species Reactivity:
Rat, Mouse, Human
Applications:
WB 1:1000ICC 1:50
Species:
Rabbit polyclonal
Gene Name:
CLVS1/2
Molecular Reference:
~35 kDa
Cite This Antibody:
PhosphoSolutions Cat# 317-CLAV, RRID:AB_2492058
Antigen/Purification: ExpandCollapse

The antigen is a synthetic peptide taken from the C-terminus of rat clavesin 1.

The antibody is prepared from serum by affinity purification using a column to which the peptide antigen was coupled.

Biological Significance: ExpandCollapse

Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).

Synonyms: ExpandCollapse
  • 4 antibody
  • C6orf212 antibody
  • C6orf213 antibody
  • Clavesin 1 antibody
  • Clavesin 2 antibody
  • CRALBPL antibody
  • FLJ37248 antibody
  • MGC120572 antibody
  • MGC34646 antibody
  • OTTHUMP00000017122 antibody
  • Retinaldehyde binding protein 1 like 1 antibody
  • Retinaldehyde binding protein 1 like 2 antibody
  • RLBP1L1 antibody
  • RLBP1L2 antibody

Storage

100 µl in PBS + 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

General References

Yohei Katoh, Brigitte Ritter, Thomas Gaffry, Francois Blondeau, Stefan Höning and Peter S. McPherson (2009) the clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. Journal of Biological Chemistry Oct 2;284(40):27646-54.

Zhao S, Xu C, Qian H, Lv L, Ji C, Chen C, Zhao X, Zheng D, Gu S, Xie Y, Mao Y (2008) Cellular retinaldehyde-binding protein-like (CRALBPL), a novel human Sec14p-like gene that is upregulated in human hepatocellular carcinomas, may be used as a marker for human hepatocellular carcinomas. DNA Cell Biol. Mar; 27(3):159-63.

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Clavesin 1/2 Antibody
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~35 kDa clavesin protein.

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