Neuronal marker for ICC and Western blot
- Affinity purified
- Rat, Mouse, Human
- WB 1:1,000ICC 1:50
- Rabbit polyclonal
- Gene Name:
- Molecular Reference:
- ~35 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 317-CLAV, RRID:AB_2492058
The antigen is a synthetic peptide taken from the C-terminus of rat clavesin 1.
The antibody is prepared from serum by affinity purification using a column to which the peptide antigen was coupled.
Biological Significance: ExpandCollapse
Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).