Clavesin 1/2 Antibody

Catalog #: 317-CLAV Categories: , , , Datasheet:

$109.00$365.00

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Neuronal marker for ICC and Western blot

Formulation:
Affinity purified
Species Tested:
Rat
Expected Reactivity:
Mouse, Human
Applications:
WB 1:1000ICC 1:50 Don't see your application?
Species:
Rabbit polyclonal
Gene Name:
CLVS1/2
Molecular Weight:
~35 kDa
Cite This Antibody:
PhosphoSolutions Cat# 317-CLAV, RRID:AB_2492058
Antigen/Purification: ExpandCollapse

The antigen is a synthetic peptide taken from the C-terminus of rat clavesin 1.

The antibody is prepared from serum by affinity purification using a column to which the peptide antigen was coupled.

Biological Significance: ExpandCollapse

Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).

Synonyms: ExpandCollapse
  • 4 antibody
  • C6orf212 antibody
  • C6orf213 antibody
  • Clavesin 1 antibody
  • Clavesin 2 antibody
  • CRALBPL antibody
  • FLJ37248 antibody
  • MGC120572 antibody
  • MGC34646 antibody
  • OTTHUMP00000017122 antibody
  • Retinaldehyde binding protein 1 like 1 antibody
  • Retinaldehyde binding protein 1 like 2 antibody
  • RLBP1L1 antibody
  • RLBP1L2 antibody

Storage

100 µl in PBS + 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific Protocols

Immunocytochemistry

Rat Hippocampal neurons.

Western Blotting

Click here to view our protocols page for Western blotting and lysate preparation.

Product Specific References for Applications and Species

Immunocytochemistry: Rat


Immunocytochemistry: Rat
PMID Dilution Publication
19651769 1:50 Katoh, Y., et al. 2009 The clavesin family, neuron-specific lipid-and clathrin-binding Sec14 proteins regulating lysosomal morphology. Journal of Biological Chemistry, 284(40), pp.27646-27654.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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