Great for staining the nuclei of activated neurons!
- Protein G purified
- Bovine, Human, Mouse, Rat
- WB 1:2000IF 1:1000IHC 1:1000
- Mouse Monoclonal
- Gene Name:
- Molecular Reference:
- ~50 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 309-cFOS, RRID:AB_2632380
The antigen is recombinant full length human c-FOS expressed in and purified from E. Coli.
The antibody is protein G purified from culture supernatant.
Biological Significance: ExpandCollapse
c-FOS is a member of the FOS transcription factor family which forms dimers with c-JUN to produce the Activator Protein 1 (AP-1) complex which plays a key role in critical cellular processes such as cell proliferation, differentiation and apoptosis (Chiu et al., 1988). c-FOS expression has been demonstrated to be a useful marker of neuronal activation as it is rapidly induced following various stimuli (Hoffman et al., 1993). Additionally, c-FOS has been shown to be overexpressed in a variety of malignant tumor types (Milde-Langosch 2005).