Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Xenopus
- WB 1:1000
- Molecular Reference:
- ~83 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p120-3337, RRID:AB_2492049
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
β-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of β-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37and Thr41 by glycogen synthase kinase 3β (GSK3β) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation regulated process that prevent β-catenin hyperphosphorylation by GSK3β are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).