Great for identifying specific neuronal cell types in IHC!
- 100 µl
- Protein G Purified
- Rat, Mouse, Human, Bovine
- WB 1:2,000IF 1:1,000
- Mouse Monoclonal
- Gene Name:
- Molecular Reference:
- ~ 28 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 302-CALB, RRID:AB_2560939
The antigen is a recombinant full length human calbindin purified from E. coli.
The antibody is Protein G purified.
Biological Significance: ExpandCollapse
Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).