Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- 100% Homology:
- Mouse, Human, Xenopus, Bovine, Chicken, Non-human primate, Zebra fish, Sheep, Canine
- WB 1:250
- Gene Name:
- Molecular Reference:
- ~60 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p117-295, RRID:AB_2492048
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser295 of human beclin-1.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Beclin-1 plays a key role in tumor suppression and autophagy. It has been suggested that autophagy proteins such as beclin-1 can inhibit tumorigenesis and that decreased expression of these proteins may contribute to the development of human malignancies (Liang et al., 1999). Akt-mediated phosphorylation of beclin-1 at Ser295 has been shown to decrease autophagy and promote oncogenesis (Wang et al., 2012).