Affinity purified from pooled serum. Learn more.

Beclin-1 (Ser234) Antibody

Catalog #: p117-234 Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Bovine, Non-human primate, Sheep, Canine
Applications:
WB 1:250
Species:
Rabbit
Gene Name:
BECN1
Molecular Reference:
~60 kDa
Cite This Antibody:
PhosphoSolutions Cat# p117-234, RRID:AB_2492047
Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of human beclin-1.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho- peptide affinity columns.

Biological Significance: ExpandCollapse

Beclin-1 plays a key role in tumor suppression and autophagy. It has been suggested that autophagy proteins such as beclin-1 can inhibit tumorigenesis and that decreased expression of these proteins may contribute to the development of human malignancies (Liang et al., 1999). Beclin-1 has been shown to interact with 14-3-3 proteins through Akt-mediated phosphorylation at Ser234 (Wang et al., 2012).

Synonyms: ExpandCollapse
  • PG6 antibody
  • ATG 6 antibody
  • ATG6 antibody
  • ATG6 autophagy related 6 homolog antibody
  • Bcl-2-interacting protein beclin antibody
  • Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody
  • Beclin 1 autophagy related antibody
  • Beclin-1 antibody
  • Beclin1 antibody
  • BECN 1 antibody
  • Becn1 antibody
  • BECN1_HUMAN antibody
  • Coiled coil myosin like BCL2 interacting protein antibody
  • Coiled-coil myosin-like BCL2-interacting protein antibody
  • GT197 antibody
  • Protein GT197 antibody
  • VPS 30 antibody
  • VPS30 antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Song, X., Lee, D.H., Dilly, A.K., Lee, Y.S., Choudry, H.A., Kwon, Y.T., Bartlett, D.L. and Lee, Y.J., 2018. Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. Molecular Cancer Research. PMID: 29669822

Weh, K.M., Howell, A.B. and Kresty, L.A., 2016. Expression, modulation, and clinical correlates of the autophagy protein Beclin?1 in esophageal adenocarcinoma. Molecular carcinogenesis, 55(11), pp.1876-1885. PMID: 27696537

Richard C. Wang, Yongjie Wei, Zhenyi An, Zhongju Zou, Guanghua Xiao, Govind Bhagat, Michael White, Julia Reichelt, and Beth Levine (2012) Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation. Science 338:956-959. PMID: 23112296

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Beclin-1 ser234 Antibody
Western blot of wild type (WT) beclin-1 expressed in HeLa cell lysate showing specific immunolabeling of beclin-1 phosphorylated at Ser234. This immunolabeling is decreased in the beclin-1 double alanine substitution mutant (S234A, S295A: Mut) expressed in HeLa cell lysate.

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