Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- 100% Homology:
- Rat, Mouse, Human, Bovine, Non-human primate, Sheep, Canine
- WB 1:250
- Gene Name:
- Molecular Reference:
- ~60 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p117-234, RRID:AB_2492047
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of human beclin-1.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho- peptide affinity columns.
Biological Significance: ExpandCollapse
Beclin-1 plays a key role in tumor suppression and autophagy. It has been suggested that autophagy proteins such as beclin-1 can inhibit tumorigenesis and that decreased expression of these proteins may contribute to the development of human malignancies (Liang et al., 1999). Beclin-1 has been shown to interact with 14-3-3 proteins through Akt-mediated phosphorylation at Ser234 (Wang et al., 2012).