Affinity purified from pooled serum. Learn more.

Amyloid Precursor Protein Antibody

Catalog #: 144-APP Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Non-human primate, Canine
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
APP
Molecular Weight:
~115 kDa
Cite This Antibody:
PhosphoSolutions Cat# 144-APP, RRID:AB_2492039
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat APP.

The antibody is prepared from pooled rabbit serum by affinity purification on a column made with the C-terminal peptide used as antigen.

 

Biological Significance: ExpandCollapse

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer’s disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).

Synonyms: ExpandCollapse
  • A4 amyloid protein antibody
  • A4_HUMAN antibody
  • AAA antibody
  • ABETA antibody
  • ABPP antibody
  • AD1 antibody
  • AICD-50 antibody
  • AICD-57 antibody
  • AICD-59 antibody
  • AID(50) antibody
  • AID(57) antibody
  • AID(59) antibody
  • Alzheimer disease amyloid protein antibody
  • Amyloid beta (A4) precursor protein antibody
  • Amyloid beta A4 protein antibody
  • Amyloid beta protein antibody
  • Amyloid intracellular domain 50 antibody
  • Amyloid intracellular domain 57 antibody
  • Amyloid intracellular domain 59 antibody
  • Amyloid precursor protein antibody
  • APP antibody
  • APPI antibody
  • Beta amyloid peptide antibody
  • Beta-amyloid precursor protein antibody
  • Beta-APP40 antibody
  • Beta-APP42 antibody
  • C31 antibody
  • Cerebral vascular amyloid peptide antibody
  • CTFgamma antibody
  • CVAP antibody
  • Gamma-CTF(50) antibody
  • Gamma-CTF(57) antibody
  • Gamma-CTF(59) antibody
  • peptidase nexin II antibody
  • PN 2 antibody
  • PN II antibody
  • PN-II antibody
  • PN2 antibody
  • PreA4 antibody
  • Protease nexin II antibody
  • Protease nexin-II antibody
  • S-APP-alpha antibody
  • S-APP-beta antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

General References

Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processingand synaptic function. Neuron 37:925-937.
Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, May PC, Ni B (2003) Regulation of amyloid precursorprotein (APP) phosphorylation and processing by p35/cdk5 and p25/cdk5. FEBS Lett 547:193-196

 

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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Amyloid Precursor Protein Antibody
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115 kDa APP protein.

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