Affinity purified from pooled serum. Learn more.

Alpha Synuclein (Ser129) Antibody

Catalog #: p1571-129 Categories: , Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Bovine, Non-human primate, Canine
Applications:
WB 1:1000
Species:
Rabbit
Gene Name:
SNCA
Molecular Weight:
~15 kDa
Cite This Antibody:
PhosphoSolutions Cat# p1571-129, RRID:AB_2492038
Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

Biological Significance: ExpandCollapse

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alphasynuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).

Synonyms: ExpandCollapse
  • Alpha synuclein antibody
  • Alpha-synuclein antibody
  • Alpha-synuclein, isoform NACP140 antibody
  • alphaSYN antibody
  • MGC105443 antibody
  • MGC110988 antibody
  • MGC127560 antibody
  • MGC64356 antibody
  • NACP antibody
  • Non A beta component of AD amyloid antibody
  • Non A4 component of amyloid antibody
  • Non A4 component of amyloid precursor antibody
  • Non-A beta component of AD amyloid antibody
  • Non-A-beta component of alzheimers disease amyloid , precursor of antibody
  • Non-A4 component of amyloid precursor antibody
  • Non-A4 component of amyloid, precursor of antibody
  • OTTHUMP00000218549 antibody
  • OTTHUMP00000218551 antibody
  • OTTHUMP00000218552 antibody
  • OTTHUMP00000218553 antibody
  • OTTHUMP00000218554 antibody
  • PARK 1 antibody
  • PARK 4 antibody
  • PARK1 antibody
  • PARK4 antibody
  • Parkinson disease (autosomal dominant, Lewy body) 4 antibody
  • Parkinson disease familial 1 antibody
  • SNCA antibody
  • Snca synuclein, alpha (non A4 component of amyloid precursor) antibody
  • SYN antibody
  • Synuclein alpha antibody
  • Synuclein alpha 140 antibody
  • Synuclein, alpha (non A4 component of amyloid precursor) antibody
  • SYUA_HUMAN antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Corwin, C., Nikolopoulou, A., Pan, A.L., Nunez-Santos, M., Vallabhajosula, S., Serrano, P., Babich, J. and Figueiredo-Pereira, M.E., 2018. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. Journal of neuroinflammation, 15(1), p.272. PMID: 30236122

 

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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Alpha Synuclein ser129 Antibody
Western blot of rat cortical lysate showing specific immunolabeling of the ~15 kDa alpha synuclein protein phosphorylated at Ser129 in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding non-phosphopeptide (not shown).

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