Alpha Synuclein Antibody

Catalog #: 107-ASYN Categories: , Datasheet:

$109.00$365.00

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Mouse monoclonal antibody

Formulation:
Protein G purified
Specificity:
Rat, Mouse, Human
Applications:
WB 1:1,000IF 1:500
Species:
Mouse
Gene Name:
SNCA
Molecular Reference:
~15 kDa
Cite This Antibody:
PhosphoSolutions Cat# 107-ASYN, RRID:AB_2492037
Antigen/Purification: ExpandCollapse

The antigen is a full length human alpha synuclein expressed in E. Coli.

The antibody is Protein G purified.

Biological Significance: ExpandCollapse

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson’s disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).

Storage

100 µl liquid containing 10 mM sodium azide.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C(2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem Jan 7;275(1): 390-7.

Chartier-Harlin, MC. et al. Alpha-synuclein locus duplication as a cause of familial Parkinson’s disease. Lancet 364: 1167-1169 (2004).

Singleton, AB et al. Alpha-synuclein locus triplication causes Parkinson’s disease. Science 302:841 (2003).

Alpha Synuclein Antibody
Western blot of rat brain lysate showing specific immunolabeling of the ~ 15 kDa alpha synuclein protein.
Alpha Synuclein Antibody
Mixed neuron-glial cultures stained with alpha-synuclein (red) and chicken MAP2 (cat.# 1100-MAP2) (green). The alpha-synuclein antibody stains vesicular structures, the perikarya and processes of the neurons in this image.

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