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Alpha Synuclein Antibody

Chicken Polyclonal Antibody

Catalog #: SNCA-1010 Category: Datasheet:

$185.00

Size:
100 µl
Formulation:
Total IgY Fraction
Expected Reactivity:
Human, Mouse, Rat
Applications:
WB 1:1000-1:5000IHC 1:100-1:500ICC 1:100-1:500
Host Species:
Chicken Polyclonal
Gene Name:
SNCA, NACP, PARK1
Molecular Weight:
14 kDa
Cite This Antibody:
Aves Labs, Cat# SNCA-1010, RRID:AB_2827809
Antigen/Purification: ExpandCollapse

Immunogen is full-length human alpha-synuclein (UniProtKB – P37840) produced in E.Coli.

Chickens were immunized with recombinant human α-synuclein protein (expressed in bacteria). After repeated injections, immune eggs were collected, the IgY fractions were purified from the yolks, and the IgY concentration adjusted to 10 mg/ml. Finally, the antibody preparation was filter-sterilized.

Biological Significance: ExpandCollapse

Alpha-synuclein (SNCA), also known as PARK1, NACP, PARK4, is a member of the synuclein family, which also includes beta- and gamma-synuclein. Alpha-synuclein is a highly-conserved protein known to be abundant in neurons and especially presynaptic terminals where it serves multiple roles including regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Functionally, alpha synuclein has been implicated in synaptic plasticity (Liu 2004) and the assembly of snare complexes (Burre 2010) and it is known to be associated with various neuropathologies including Parkinson’s Disease, Lewy Body Dementia, and Alzheimer’s Disease, where it forms insoluble protein aggregates. Early studies of amyloid deposits in the brains of Alzheimer’s patients revealed two previously uncharacterized peptides in addition to the amyloid beta fragment (Ueda 1993), both of which were found to correspond to alpha-synuclein (SNCA). Later studies confirmed that aggregated alpha-synuclein proteins are present in brain lesions (Lewy bodies) that are hallmarks of neurodegenerative synucleinopathies and that alpha synuclein likely plays a role in the pathogenesis of Parkinson’s disease, Lewy body dementia, and Alzheimer’s disease among other neuropathologies.

Synonyms: ExpandCollapse

Alpha synuclein antibody
Alpha-synuclein antibody
Alpha-synuclein, isoform NACP140 antibody
alphaSYN antibody
MGC105443 antibody
MGC110988 antibody
MGC127560 antibody
MGC64356 antibody
NACP antibody
Non A beta component of AD amyloid antibody
Non A4 component of amyloid antibody
Non A4 component of amyloid precursor antibody
Non-A beta component of AD amyloid antibody
Non-A-beta component of alzheimers disease amyloid , precursor of antibody
Non-A4 component of amyloid precursor antibody
Non-A4 component of amyloid, precursor of antibody
OTTHUMP00000218549 antibody
OTTHUMP00000218551 antibody
OTTHUMP00000218552 antibody
OTTHUMP00000218553 antibody
OTTHUMP00000218554 antibody
PARK 1 antibody
PARK 4 antibody
PARK1 antibody
PARK4 antibody
Parkinson disease (autosomal dominant, Lewy body) 4 antibody
Parkinson disease familial 1 antibody
SNCA antibody
Snca synuclein, alpha (non A4 component of amyloid precursor) antibody
SYN antibody
Synuclein alpha antibody
Synuclein alpha 140 antibody
Synuclein, alpha (non A4 component of amyloid precursor) antibody
SYUA_HUMAN antibody

Storage

Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS,” pH 7.2) with sodium azide (0.02%, w/v) added as a preservative.

Store at 4˚C in the dark. Under these conditions, the antibody should have a shelf life of at least twelve months, provided they remain sterile. Do not freeze these antibodies unless you want to store them for longer periods of time. Note, however, that each time an antibody preparation is frozen, about half of its binding activity may be lost.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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