- 100 µl
- Antigen affinity purified from pooled serum
- Species Tested:
- Expected Reactivity:
- WB 1:1000ICC 1:500
- Host Species:
- Rabbit Polyclonal
- Gene Name:
- Molecular Weight:
- ~ 17 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 91-AIF1, RRID:AB_2868532
The antigen is full-length human AIF1/Iba1 protein expressed in and purified from E. coli.
The antibody was prepared from pooled rabbit serum by affinity purification using a column to which the protein immunogen was coupled.
Biological Significance: ExpandCollapse
AIF1, allograft inflammatory factor-1, (also known as Iba1, Ionized calcium binding adaptor molecule 1) is a 17 kDa protein that is a pro-inflammatory molecule that mediates calcium signals (Ito, D. et al 1998). During inflammation, increased expression of AIF1 occurs in microglia, macrophages, T-cells, synoviocytes, and adipocytes (Watano, K., et al, 2001). Expression of AIF-1 has been observed in healthy brains and varies throughout the day, gaining the highest expression in the prefrontal and parietal cortices when sleeping (Romcy-Pereira, R.N, et al, 2009). Increased expression of AIF1 has been observed in several diseases including breast cancer (Liu, S., et al 2008), atherosclerosis (Utans, U., et al, 1995), and rheumatoid arthritis (Kimura, M., et al, 2007).
allograft inflammatory factor-1
Ionized calcium binding adaptor molecule 1