Adenylate Cyclase III Antibody

Catalog #: 85-AC3 Categories: , , Datasheet:

$109.00$365.00

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Use in IHC to stain neuronal cilia!

Formulation:
Affinity Purified
Species Reactivity:
Rat, Mouse, Human
Applications:
WB 1:2000IF 1:500
Species:
Rabbit polyclonal
Gene Name:
ADCY3
Molecular Reference:
~160 kDa
Cite This Antibody:
PhosphoSolutions Cat# 85-AC3, RRID:AB_2492029
Antigen/Purification: ExpandCollapse

The antigen is a synthetic peptide corresponding to amino acid residues from the C-terminal region of rat adenylate cyclase III conjugated to KLH.

The antibody is affinity purified rabbit serum.

Biological Significance: ExpandCollapse

Adenylate cyclase is the enzyme which produces the “second messenger” signaling molecule, cAMP from ATP. Type III adenylate cyclase is localized to the membranes surrounding neuronal cilia. Much is currently unknown about the function of primary cilia in vertebrates, however, recent work has begun to explore their role in neuronal signaling and neurogenesis (Fuchs and Schwark, 2004; Louvi and Grove 2011).

Synonyms: ExpandCollapse
  • AC-III antibody
  • AC3 antibody
  • ADCY3 antibody
  • ADCY3_HUMAN antibody
  • adenylate cyclase 3 antibody
  • Adenylate cyclase antibody
  • Adenylate cyclase type 3 antibody
  • Adenylate cyclase type III antibody
  • Adenylyl cyclase 3 antibody
  • ATP pyrophosphate lyase antibody
  • ATP pyrophosphate-lyase 3 antibody
  • olfactive type antibody

Storage

100 μl in PBS.  Store at –20° C in undiluted aliquots;

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Fuchs JL, Schwark HD. (2004) Neuronal primary cilia: a review. Cell Biol Int. 28:111-8.

Louvi A and Grove EA. (2011) Cilia in the CNS: the quiet organelle claims center stage. Neuron 69:1046-1060.

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Adenylate Cyclase III Antibody
Western blot of rat cortical lysate showing specific immunolabeling of the ~160 kDa adenylate cyclase III protein.
Adenylate Cyclase III Antibody
Immunofluorescence of cultured rat neurons and glia showing strong staining of neuronal cilia using our anti-adenylate cyclase III antibody (red) and axonal and dendritic staining of alpha II spectrin (cat. # 98-A2SM) (green) revealing the submembranous cytoskeleton and DNA (blue).

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