Our Anti-Visinin-Like Protein 1 (VSNL1) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Visinin-Like Protein 1 (VSNL1) and is Protein G purified. It is great for use in WB, IHC, ICC.
Western blot of rat cerebellar lysate showing specific immunolabeling of the ~22 kDa VSNL1 protein.
Anti-Visinin-Like Protein 1 (VSNL1) Antibody
Visinin-Like Protein 1 (VSNL1)
Visinin-like protein 1 (VSNL1), also known as VILIP1, is a calcium sensor protein expressed exclusively in neurons. Highest levels of VSNL1 expression are found in cerebellar Purkinje cells. VSNL1 has been implicated in the modulation of cell signaling cascades via regulation of adenyl cyclase activity (Braunewell et al., 1997). Additionally, VSNL1 has been associated with amyloid plaques and neurofibrillar tangles in Alzheimer’s disease (Schnurra et al., 2001).
Protein G Purified
ICC, IHC, WB
Recombinant human VSNL1 purified from E. coli.
Bovine, Human, Mouse, Rat
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Braunewell, K.H., Spilker, C., Behnisch, T. and Gundelfinger, E.D., 1997. The Neuronal Calcium‐Sensor Protein VILIP Modulates Cyclic AMP Accumulation in Stably Transfected C6 Glioma Cells: Amino‐Terminal Myristoylation Determines Functional Activity. Journal of Neurochemistry, 68(5), pp.2129-2139. PMID: 9109541
Schnurra, I., Bernstein, H.G., Riederer, P. and Braunewell, K.H., 2001. The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease? Neurobiology of Disease, 8(5), pp.900-909. PMID: 11592857
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