Anti-TREM2 Antibody

Name: Anti-TREM2 Antibody
Brand: PhosphoSolutions
SKU: 2006-TREM2
Price: 415.0 USD
Availability: InStock

from PhosphoSolutions Datasheet

Trial Size

Pooled Serum

Our Anti-TREM2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse TREM2 and is antigen affinity purified from pooled serum. It is great for use in WB, ICC.

Product Type

Primary Antibody

Species Reactivity

Human, Mouse

Expected Reactivity

Human

Applications

ICC, WB

Host Species

Rabbit

Format

Antigen Affinity Purified from Pooled Serum

Gene Name

TREM2

Molecular Weight

28 kDa

Go to Full Product Details

Immunofluoresence of FLAG-tagged TREM2 transfected COS cells showing TREM2 (cat. 2006-TREM2, 1:150) staining in red and FLAG staining in green causing positive transfected cells to appear yellow. DNA is stained blue with DAPI.

Western blot of mouse whole brain lysate showing specific immunolabeling of the ~28 kDa TREM2 protein.

Volume: 100 µL

Variant

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$415

Quantity:

Bulk Order Anti-TREM2 Antibody

Product Details

Target

TREM2

Target Description

Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer’s disease (Schmid, C.D., et al., 2002). TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells (Cherry, J.D. et al., 2014). TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways (Jay,T.R, et al., 2017). TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques (Gratuze, M., et al., 2018). In early brain development, TREM2 is essential for synaptic pruning (Filipello, F. et al., 2018).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ICC, WB

Host Species

Rabbit

Gene Name

TREM2

Molecular Weight

28 kDa

Antigen

Recombinant human TREM2 protein expressed in and purified from E. Coli.

Species Reactivity

Human, Mouse

Expected Reactivity

Human

Antibody Registry ID

AB_2868514

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
ICC: 1:150

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~28 kDa TREM2 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Triggering receptor expressed on myeloid cells 2

UniProt Details

UniProt (Human): Q9NZC2
UniProt (Immunogen Species): Q9NZC2

NCBI Gene ID

54209

Product Specific Protocols

Western Blot Protocol: Download

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Anti-TREM2 Antibody

Our Anti-TREM2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse TREM2 and is antigen affinity purified from pooled serum. It is great for use in WB, ICC.