Name: Anti-Testicular Receptor 4 (TR4) Antibody
Brand: PhosphoSolutions
SKU: 2004-TR4
Price: 360.0 USD
Availability: InStock

Our Anti-Testicular Receptor 4 (TR4) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat Testicular Receptor 4 (TR4) and is neat serum. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Applications

WB

Host Species

Rabbit

Format

Neat Serum

Gene Name

NR2C2

Molecular Weight

64 kDa

Go to Full Product Details

Western blot of rat cerebellum lysate showing specific immunolabeling of the ~64 kDa TR4 protein.

Volume: 100 µL

Variant

Price:

$360

Quantity:

Bulk Order Anti-Testicular Receptor 4 (TR4) Antibody

Product Details

Target

Testicular Receptor 4 (TR4)

Target Description

Testicular receptor 4 (TR4) is a member of the orphan nuclear receptor superfamily. Data suggests that TR4 may function as a regulator that modulates many signaling pathways. It has been suggested that TR4 is required for normal cerebellar development as TR4 knockout mice exhibit behavioral deficits in motor coordination (Chen, YT et al.,2008) and plays important roles in growth, embryonic and early postnatal survival (Collins, LL, et al., 2004).

Format

Neat Serum

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Host Species

Rabbit

Gene Name

NR2C2

Molecular Weight

64 kDa

Antigen

Fusion protein from the N-terminal region of mouse TR4

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2492265

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Production Notes

Neat Serum

Buffer

Neat serum

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~64 kDa TR4 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

hTAK1 antibody, Nr2c2 antibody, NR2C2_HUMAN antibody, Nuclear hormone receptor TR4 antibody, Nuclear receptor subfamily 2 group C member 2 antibody, Orphan nuclear receptor TAK1 antibody, Orphan nuclear receptor TR4 antibody, TAK1 antibody, Testicular nuclear receptor 4 antibody, Testicular receptor 4 antibody, TR2R1 antibody, TR4 antibody, TR4 nuclear hormone receptor antibody

UniProt Details

UniProt (Human): P49116
UniProt (Immunogen Species): P49117

NCBI Gene ID

22026

Product Specific References for Applications and Species

Western Blot: Human | Mouse

Western Blot: Human
PMID	Dilution	Publication
21670149	not listed	Cui, S., et al. 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920	not listed	Tanabe, O., et al. 2007. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400	not listed	Tanabe, O., et al. 2007. Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.

Western Blot: Mouse
PMID	Dilution	Publication
24662048	not listed	Cui, S., et al. 2014. PGC-1 coactivator activity is required for murine erythropoiesis. Molecular and Cellular Biology, 34(11), pp.1956-1965.
22042865	not listed	Campbell, A.D., et al. 2011. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proceedings of the National Academy of Sciences, 108(46), pp.18808-18813.
21670149	not listed	Cui, S., et al. 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920	not listed	Tanabe, O., et al. 2007. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400	not listed	Tanabe, O., et al. 2007. Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.

Product Specific Protocols

Western Blot Protocol: Download

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Anti-Testicular Receptor 4 (TR4) Antibody

Our Anti-Testicular Receptor 4 (TR4) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat Testicular Receptor 4 (TR4) and is neat serum. It is great for use in WB.