Anti-SHP1 (Ser-591), Phosphospecific Antibody

Our SHP1 (Ser-591) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat SHP1 (Ser-591) and is antigen affinity purified. It is great for use in WB.



SKU: SP1531

Volume: 100 µL
Price:
Sale price$329

Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
18617527not listedSimoneau, M, et al. 2008. Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. The Journal of Biological Chemistry, 25544-25556.
Immunocytochemistry: Mouse
PMID Dilution Publication
352584551:500Ben-Shmuel, A, et al. 2022. Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity. Elife, e73282.
338466411:2000Weng, JH, et al. 2021. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nature Metabolism, 513-522.
Western Blot: Human
PMID Dilution Publication
38637625not listedSabag, B, et al. 2024. Dysfunctional natural killer cells can be reprogrammed to regain anti-tumor activity. The EMBO Journal, 0.
24947019not listedMani, R, et al. 2015. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia, 346-355.
23720348not listedZhou, X, et al. 2013. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. American Journal of Physiology. Renal Physiology, F362-369.
21527515not listedSalas, A, et al. 2011. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood, 5941-5952.
18617527not listedSimoneau, M, et al. 2008. Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. The Journal of Biological Chemistry, 25544-25556.
Western Blot: Mouse
PMID Dilution Publication
352584551:1000Ben-Shmuel, A, et al. 2022. Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity. Elife, e73282.
338466411:2000Weng, JH, et al. 2021. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nature Metabolism, 513-522.
31033226not listedWang, H, et al. 2019. Sickle cell disease up-regulates vasopressin, aquaporin 2, urea transporter A1, Na-K-Cl cotransporter 2, and epithelial Na channels in the mouse kidney medulla despite compromising urinary concentration ability. Physiological reports, e14066.
30373850not listedOrmonde, J, et al. 2018. TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK. Journal of immunology (Baltimore, Md. : 1950), 3431-3442.
27271569not listedMoogk, D, et al. 2016. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. Journal of immunology (Baltimore, Md. : 1950), 644-654.
25391900not listedWang, H, et al. 2015. PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2. American Journal of Physiology. Renal Physiology, F140-148.
24990897not listedZhou, X, et al. 2014. Leishmania infantum-chagasi activates SHP-1 and reduces NFAT5/TonEBP activity in the mouse kidney inner medulla. American Journal of Physiology. Renal Physiology, F516-524.
20351292not listedZhou, X, et al. 2010. Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proceedings of the National Academy of Sciences of the United States of America, 7072-7077.
Western Blot: Rat
PMID Dilution Publication
24140598not listedTibaldi, E, et al. 2014. The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling. Biochimica et Biophysica acta, 288-298.

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