Anti-Shank3 Antibody (N367/62)

Our Anti-Shank3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N367/62. It detects mouse and rat Shank3, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

SKU: 75-344

Volume: 100 µL
Sale price$374

Product Specific References for Applications and Species

Electron Microscopy: Rat
PMID Dilution Publication
271443021:250Tao-Cheng, J.H., et al. 2016. Zinc stabilizes Shank3 at the postsynaptic density of hippocampal synapses. PLoS One, e0153979.
Immunocytochemistry: Rat
PMID Dilution Publication
305242321:100Ha, H.T., et al. 2018. Shank and zinc mediate an AMPA receptor subunit switch in developing neurons. Frontiers in Molecular Neuroscience, 405.
265478311:400MacGillavry, H.D., et al. 2016. Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses.. European Journal of Neuroscience, 179-193.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
311899581:100Zhou, Y., et al. 2019. Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature , 326-331.
Immunoprecipitation: Mouse
PMID Dilution Publication
34852231not listedLautz, J.D., et al. 2021. Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states. Cell Reports, 110076.
Western Blot: Mouse
PMID Dilution Publication
379251731:500Cao, Q, et al. 2023. Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model. Aging, 11697-11719.
36587867not listedLiu, P., et al. 2022. Degradation of Perineuronal Nets in the Cerebellar Interpositus Nucleus Ameliorated Social Deficits in Shank3-deficient Mice. Neuroscience, 29-38.
350225311:1000Tzanoulinou, S., et al. 2022. Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism. . Molecular Psychiatry, 2080-2094.
33229412not listedPandian, S., et al. 2020. Myosin va brain-specific mutation alters mouse behavior and disrupts hippocampal synapses. eNeuro, .
320198291:2000Perfitt, T.L., et al. 2020. Neuronal L-type calcium channel signaling to the nucleus requires a novel CaMKIIα-Shank3 interaction. Journal of Neuroscience, 2000-2014.
316027841:500Rein, B., et al. 2020. Diminished social interaction incentive contributes to social deficits in mouse models of autism spectrum disorder. Genes, Brain, and Behavior, e12610.
31332372not listedGuo, B., et al. 2019. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice. Nature Neuroscience, 1223-1234.
30302388not listedDrapeau, E., et al. 2018. Behavioral phenotyping of an improved mouse model of Phelan–McDermid syndrome with a complete deletion of the Shank3 gene. eNeuro, .
295313621:500Qin, L., et al. 2018. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nature Neuroscience, 564-574.
26687841not listedZhou, Y., et al. 2016. Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.. Neuron, 147-162.
266273101:500Berg, J.M., et al. 2015. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.. Neuron, 1173-1191.
Western Blot: Rat
PMID Dilution Publication
305242321:100Ha, H.T., et al. 2018. Shank and zinc mediate an AMPA receptor subunit switch in developing neurons. Frontiers in Molecular Neuroscience, 405.
281391981:500Harony-Nicolas, H., et al. 2017. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.. Elife, e18904.
240894841:500Duffney, L.J., et al. 2013. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.. Journal of Neuroscience, 15767-15778.

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