Anti-Semaphorin-3A (Central region) Antibody (M317)

Name: Anti-Semaphorin-3A (Central region) Antibody
Brand: PhosphoSolutions
SKU: SM3171
Price: 309.0 USD
Availability: InStock

from PhosphoSolutions Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

M317

Applications

Host Species

Mouse

Format

Antigen Affinity Purified

Gene Name

SEMA3A

Molecular Weight

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Western blots of human recombinant Sema3A/Fc chimera (95/125 kDa) (lanes 1-4). The blots were probed with rabbit polyclonal Sema3A (Central region) at 1:250 (lane 1) and 1:1000 (lane 2) and mouse monoclonal Sema3A (Central region) at 1:250 (lane 3) and 1:1000 (lane 4). Both antibodies recognize the 95 kDa and 125 kDa forms of the recombinant Sema3A.

Volume: 100 µL

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Product Details

Target

Semaphorin-3A (Central region)

Target Description

One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI-anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co-receptors, Neuropilin-1 and Plexin-A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A-containing region. Thus, Sema3A and its co-receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.

Format

Antigen Affinity Purified

Clonality

Monoclonal

Clone

M317

Isotype

IgG1

Applications

Host Species

Mouse

Gene Name

SEMA3A

Molecular Weight

Antigen

Clone M317 was generated from a synthetic peptide (coupled to carrier protein) corresponding to amino acids in the central region of human Sema3A. The sequence used is highly conserved in rat and mouse Sema3A, and has low homology to other semaphorin family members.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:500

Conjugate

Unconjugated

Specificity

The antibody detects a 95kDa* protein corresponding to the apparent molecular mass of Sema3A on SDS-PAGE immunoblots of human recombinant Sema3A and adult mouse brain lysates.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Sema3A, Semaphorin III

UniProt Details

UniProt (Human): Q14563
UniProt (Immunogen Species): Q14563

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Anti-Semaphorin-3A (Central region) Antibody (M317)

Anti-Semaphorin-3A (Central region) Antibody
SKU: SM3171

Bulk Order Anti-Semaphorin-3A (Central region) Antibody

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Anti-Semaphorin-3A (Central region) Antibody (M317)

Anti-Semaphorin-3A (Central region) Antibody SKU: SM3171

Bulk Order Anti-Semaphorin-3A (Central region) Antibody

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Anti-Semaphorin-3A (Central region) Antibody
SKU: SM3171