Anti-PYK2 (C-terminal region) Antibody (M229)

Name: Anti-PYK2 (C-terminal region) Antibody
Brand: PhosphoSolutions
SKU: PM2291
Price: 255.0 USD
Availability: InStock

from PhosphoSolutions

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

M229

Applications

ICC, WB

Host Species

Mouse

Format

Protein A Purified

Gene Name

PTK2B

Molecular Weight

116

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Western blot analysis of mouse brain. The blot was probed with anti-PYK2 (C-terminal region) antibody at 1:250 (lane 1), 1:500 (lane 2), 1:1000 (lane 3), and 1:2000 (lane 4).

Volume: 100 µL

Variant

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$255

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Product Details

Target

PYK2 (C-terminal region)

Target Description

Protein tyrosine kinase, Pyk2 (CAKb, RAFTK, CADTK), is a nonreceptor tyrosine kinase structurally related to focal adhesion kinase (FAK). Pyk2 is predominantly expressed in cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for the G-protein-coupled receptors and MAP kinase signaling pathway. It plays an important role in cell spreading and migration of various cell types. In T-cells, Pyk2 is tyrosine phosphorylated and activated upon ligation of TCR. Phosphorylation of Tyr-402 is required for the phosphorylation of other tyrosines in Pyk2 and provides a binding site for Fyn SH2 during T-cell activation.

Format

Protein A Purified

Clonality

Monoclonal

Clone

M229

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

PTK2B

Molecular Weight

116

Antigen

Clone M229 was generated from a recombinant human PYK2 protein that included amino acids residues in the C-terminal region. This sequence is conserved in rat and mouse PYK2, and has low homology to other related kinases.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:1000
ICC: 1:100

Conjugate

Unconjugated

Specificity

The antibody detects a 116 kDa* band corresponding to PYK2 on SDS-PAGE immunoblots of mouse brain tissue.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

CAKbeta, FAK2

UniProt Details

UniProt (Human): Q14289
UniProt (Immunogen Species): Q14289

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Anti-PYK2 (C-terminal region) Antibody (M229)

Anti-PYK2 (C-terminal region) Antibody
SKU: PM2291

Bulk Order Anti-PYK2 (C-terminal region) Antibody

Product Details

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Anti-PYK2 (C-terminal region) Antibody (M229)

Anti-PYK2 (C-terminal region) Antibody SKU: PM2291

Bulk Order Anti-PYK2 (C-terminal region) Antibody

Product Details

Anti-PYK2 (C-terminal region) Antibody
SKU: PM2291