The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response to cellular stress. A novel gene, PERP, is expressed in a p53-dependent manner and at high levels in apoptotic cells compared with G(1)-arrested cells. PERP induction is linked to p53-dependent apoptosis and is directly activated by p53. These data suggest that PERP is a novel effector of p53-dependent apoptosis.
Antigen Affinity Purified
Synthetic peptide corresponding to amino acids from the first extracellular loop region of the human PERP protein.
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
PBS + 0.02% NaN3
WB Brain: 1:500-1:1000
Reacts with the first extracellular loop region of the human PERP protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, P53-induced protein PIGPC1, Transmembrane protein THW